About
Pharmechanics was founded by Dr Sam Hoare in 2017, with the goal of helping pharmacologists analyze, interpret and apply their data to accelerate drug discovery and basic research on drug targets.
See testimonials here to see how I can support your science.
30+ Years of Experience
For Pharma/Biotech
For nine years as a consultant I have supported Pharma and biotech clients with their pharmacology, from early stage R&D, to clinical candidate selection, and product differentiation. With a wealth of experience of in vitro pharmacology in the pharmaceutical industry I can help you resolve the issues that are creating challenges in your drug discovery project.
For Life Science
For life science companies developing novel tools for drug discovery, I identify novel utilities and create new data analysis methodologies to increase the application and value of the products. For example, working with Montana Molecular we have developed new kinetic analysis platforms for biosensors that enable routine quantification of the kinetics of signaling for drug discovery.
For the Scientific Community
For the scientific community, I develop new open-source data analysis methods that enable investigators to analyze their data in new ways, to extract extra value from new pharmacology methodologies. I run workshops and seminars to train scientists in pharmacology data analysis, including for the National Institutes of Health Assay Guidance Manual. I have published 30+ first/senior author papers on drug discovery, molecular pharmacology and data analysis.
Dr. Sam Hoare
Before founding Pharmechanics, Sam was with the Discovery Research group at Neurocrine Biosciences, where he was Lead Pharmacologist on multiple GPCR and transporter drug targets.
He is particularly known for applying receptor kinetics to small molecule drug discovery, deriving new methods for quantifying signaling kinetics, and for deciphering the mechanism of ligand interaction with Class B GPCRs.
Sam received his PhD in biochemistry from the University of Kent in 1996 and then conducted postdoctoral research at the National Institute of Mental Health.
Our Publications
| Mechanisms of peptide and nonpeptide ligand binding to Class B G-protein-coupled receptors. Drug Discovery Today 2005 |
| Binding kinetics redefine the antagonist pharmacology of the corticotropin-releasing factor type 1 receptor. J Pharmacol Exp Ther 2012 |
| Kinetic operational models of agonism for G-protein-coupled receptors Journal of Theoretical Biology 2018 |
| Analyzing kinetic signaling data for G-protein-coupled receptors Scientific Reports 2020 |
| The importance of target binding kinetics for measuring target binding affinity in drug discovery Drug Discovery Today 2020 |
| Analyzing kinetic binding data NIH Assay Guidance Manual 2021 |
Why Choose Pharmechanics?
Pharmechanics was founded by Dr Sam Hoare in 2017, with the goal of helping pharmacologists analyze, interpret and apply their data to accelerate drug discovery and basic research on drug targets. See testimonials here to see how I can support your science.
Sam is a globally-recognized expert on industrial, applied and theoretical pharmacology. As Lead Pharmacologist at Neurocrine Biosciences, his leadership, experience and insights were instrumental in the pharmacological optimization of three novel FDA-approved therapeutics, and several more compounds in clinical development.