Currently the value of binding kinetics to drug discovery is a topic of debate. Specifically, how do binding kinetics affect occupancy when the ligand concentration is changing over time?

 

We have developed Excel-based simulators to enable you to explore this yourselves, without the need to learn how to use sophisticated software.

 

Free basic models below, and custom builds available on request. Contact sam.hoare@pharmechanics.com for more information.