Data Analysis
Data interpretation
Sometimes observations are made in drug discovery and target research that are unusual and potentially interesting, or that don’t make sense. We work with organizations to help understand and apply pharmacology assay results (see Testimonials page).
For example, some inhibitor compounds reduce the maximal response to agonist/substrate. This mechanism can be a benefit or a hindrance depending on the therapeutic goal and complicates quantification of potency.
We can help navigate this and other pharmacology issues in your projects and programs.
Troubleshooting
Sometimes pharmacology data analysis provides numbers that don’t make sense. We can help scientists troubleshoot their assays and data analysis.
For example, in the table here are results from a competition kinetics experiment with physically impossible rate values. This artifact results from very rapid dissociation of the test compound.
We worked with a team at the University of Cambridge to develop an analysis that takes this into account to quantify the compound affinity (see paper here).
Curve fitting in Excel
For simple curve fitting, e.g. sigmoid curves, Microsoft Excel provides an accessible, easy to use option.
Pharmechanics builds high capacity curve fitting solutions in Excel for drug discovery and target research organizations.
Check out the free demo model here.
Complex data analysis
Sometimes the mechanisms and resulting data in pharmacology can be complex and formidable to analyze. We employ commercial software to analyze and simulate complex pharmacology data.
For example, we work with Montana Molecular, designers and providers of very high quality biosensors, to perform analysis of time course data to enhance the value and insight of the sensors to drug discovery (see here).
We derive equations for new analysis methods (see here for examples), implement them on curve-fitting software, and can either run the analysis or train you how to do it.
Simulators
Sometimes we would like to know how a drug property, e.g. binding kinetics, translates to the in vivo drug effect. Or before starting an experiment we want to know how the system behaves, e.g. the effect of target density.
Pharmechanics creates easy-to-use simulators to enable investigators to explore their systems. For examples, see here for free PK/PD simulators that incorporate binding kinetics.
Why Choose Pharmechanics?
Pharmechanics was founded by Dr Sam Hoare in 2017, with the goal of helping pharmacologists analyze, interpret and apply their data to accelerate drug discovery and basic research on drug targets. See testimonials here to see how I can support your science.
Sam is a globally-recognized expert on industrial, applied and theoretical pharmacology. As Lead Pharmacologist at Neurocrine Biosciences, his leadership, experience and insights were instrumental in the pharmacological optimization of three novel FDA-approved therapeutics, and several more compounds in clinical development.