Publications
Drug Discovery Today, 2005
Mechanisms of peptide and nonpeptide ligand binding to Class B G-protein-coupled receptors.
J Pharmacol Exp Ther , 2012
Binding kinetics redefine the antagonist pharmacology of the corticotropin-releasing factor type 1 receptor.
Journal of Theoretical Biology, 2018
Kinetic operational models of agonism for G-protein-coupled receptors
Scientific Reports, 2020
Analyzing kinetic signaling data for G-protein-coupled receptors
Drug Discovery Today, 2020
The importance of target binding kinetics for measuring target binding affinity in drug discovery
NIH Assay Guidance Manual, 2021
Analyzing kinetic binding data
Why Choose Pharmechanics?
Pharmechanics was founded by Dr Sam Hoare in 2017, with the goal of helping pharmacologists analyze, interpret and apply their data to accelerate drug discovery and basic research on drug targets. See testimonials here to see how I can support your science.
Sam is a globally-recognized expert on industrial, applied and theoretical pharmacology. As Lead Pharmacologist at Neurocrine Biosciences, his leadership, experience and insights were instrumental in the pharmacological optimization of three novel FDA-approved therapeutics, and several more compounds in clinical development.